Primary Identifier | MGI:5509300 | Allele Type | Targeted |
Attribute String | Null/knockout | Gene | Mmp19 |
Transmission | Germline | Strain of Origin | 129P2/OlaHsd |
Is Recombinase | false | Is Wild Type | false |
molecularNote | The catalytic domain of Mmp19 (1088 bp region spanning the end of exon 3 and whole of exon 4) was replaced with a neoR cassette oriented in the opposite direction to the endogenous Mmp19. Immunoblotting and immunohistochemistry confirmed absence of MMP19 protein in cell lysates and in skin, respectively. |