| Primary Identifier | MGI:5512893 | Allele Type | Targeted |
| Attribute String | Inducible, Null/knockout, Recombinase | Gene | Sox2 |
| Transmission | Germline | Strain of Origin | 129P2/OlaHsd |
| Induced With | tamoxifen | Is Recombinase | true |
| Is Wild Type | false |
| molecularNote | Homologous recombination in ES cells inserted a cre/ERT2-PGK-neo cassette into the Sox2 locus, generating a knockin allele that functionally is a null allele of Sox2. The frt-flanked neo marker was deleted by crossing animals with Tg(ACTFLPe)9205Dym mice. Lineage tracing in embryos from tamoxifen treated females of R26YFP and Sox2Cre/ERT2 intercrosses demonstrated labelled cells at P1 in tissues that normally express Sox2 (brain, eyes, ears, oral epithelia). |
