Primary Identifier | MGI:5512910 | Allele Type | Targeted |
Attribute String | Conditional ready, Inserted expressed sequence | Gene | Pax6 |
Transmission | Germline | Strain of Origin | 129S6/SvEvTac |
Is Recombinase | false | Is Wild Type | false |
molecularNote | The coding sequence (exons 4 through 13) was replaced with a loxP site, cDNA encoding an alternatively spliced isoform for Pax6 that contains 14 amino acid inserted within the PD domain that changed its DNA binding specificity (5a), an FRT-flanked neomycin resistance/STOP cassette, loxP site and cDNA encoding Pax2. This allele expressed the 5a isoform of Pax6 (Pax6_i5a). |