| Primary Identifier | MGI:5512912 | Allele Type | Targeted |
| Attribute String | Inserted expressed sequence | Gene | Pax6 |
| Transmission | Germline | Strain of Origin | 129S6/SvEvTac |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | The coding sequence (exons 4 through 13) was replaced with a loxP site, cDNA encoding an alternatively spliced isoform for Pax6 that contains 14 amino acid inserted within the PD domain that changed its DNA binding specificity (5a), an FRT-flanked neomycin resistance/STOP cassette, loxP site and cDNA encoding Pax2. Cre-mediated recombination removed the Pax6(5a) cDNA and FRT-flanked neomycin resistance/STOP cassette and left the Pax2 cDNA intact. This allele expressed Pax2. |
