| First Author | Uddin MM | Year | 2017 |
| Journal | Nat Commun | Volume | 8 |
| Pages | 14419 | PubMed ID | 28176764 |
| Mgi Jnum | J:243937 | Mgi Id | MGI:5912716 |
| Doi | 10.1038/ncomms14419 | Citation | Uddin MM, et al. (2017) Foxn1-beta5t transcriptional axis controls CD8+ T-cell production in the thymus. Nat Commun 8:14419 |
| abstractText | The thymus is an organ that produces functionally competent T cells that protect us from pathogens and malignancies. Foxn1 is a transcription factor that is essential for thymus organogenesis; however, the direct target for Foxn1 to actuate thymic T-cell production is unknown. Here we show that a Foxn1-binding cis-regulatory element promotes the transcription of beta5t, which has an essential role in cortical thymic epithelial cells to induce positive selection of functionally competent CD8+ T cells. A point mutation in this genome element results in a defect in beta5t expression and CD8+ T-cell production in mice. The results reveal a Foxn1-beta5t transcriptional axis that governs CD8+ T-cell production in the thymus. |
