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Allele : Tg(ACTA1-TRPC6*)1Jmol transgene insertion 1, Jeffery Molkentin
Primary Identifier  MGI:5516499 Allele Type  Transgenic
Attribute String  Dominant negative, Humanized sequence, Inserted expressed sequence Gene  Tg(ACTA1-TRPC6*)1Jmol
Strain of Origin  FVB/N Is Recombinase  false
Is Wild Type  false
molecularNote  A modified human ACTA1 skeletal alpha-actin promoter (-2000 to +239drives muscle-specific expression of a dominant negative form of human TRPC6 cDNA in which three highly conserved amino acids (L678-W680) within the putative pore region were replaced with alanine residues. Line 1 was generated.
  • mutations:
  • Insertion
  • synonyms:
  • dnTRPC6 TG,
  • dnTRPC6 TG
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1 Feature

Genome

1 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

0 Driven By

2 Publication categories





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