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Allele : Tg(Pcp2-ATXN1*82Q*S776D)5Horr transgene insertion 5, Harry T Orr
Primary Identifier  MGI:5518615 Allele Type  Transgenic
Attribute String  Inserted expressed sequence Gene  Tg(Pcp2-ATXN1*82Q*S776D)5Horr
Strain of Origin  Not Specified Is Recombinase  false
Is Wild Type  false
molecularNote  The transgene consists of a mouse Pcp2 promoter driving the expression of a human ATXN1 (SCA1) cDNA with 82 CAG repeats and a serine to aspartic acid change at amino acid 776 (S776D). This is the high expressing line. The Pcp2 promoter targets transgene expression to Purkinje cells. Transgene expression was confirmed by Western blot analysis of cerebellar extracts.
  • mutations:
  • Insertion
  • synonyms:
  • ATXN1[82Q]-D776,
  • ATXN1[82Q]-D776
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1 Feature

Genome

1 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

3 Publication categories





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