Primary Identifier | MGI:5521182 | Allele Type | Targeted |
Attribute String | Humanized sequence | Gene | Slc6a4 |
Transmission | Germline | Strain of Origin | 129S6/SvEvTac |
Is Recombinase | false | Is Wild Type | false |
description | This allele represents an autism spectrum disorder (ASD) susceptibility variant, rather than a highly penetrant, monogenic cause of ASD and mice are not expected to model all aspects of ASD (J:202876). |
molecularNote | A targeted mutation in exon 2 resulted in the amino acid substitution of glycine for alanine at position 56 (G56A). Cre-mediated recombination removed the floxed neomycin resistance cassette inserted downstream of exon 4. |