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Allele : Slc6a4<tm2.1Rbl> solute carrier family 6 (neurotransmitter transporter, serotonin), member 4; targeted mutation 2.1, Randy D Blakely

Primary Identifier  MGI:5521182 Allele Type  Targeted
Attribute String  Humanized sequence Gene  Slc6a4
Transmission  Germline Strain of Origin  129S6/SvEvTac
Is Recombinase  false Is Wild Type  false
description  This allele represents an autism spectrum disorder (ASD) susceptibility variant, rather than a highly penetrant, monogenic cause of ASD and mice are not expected to model all aspects of ASD (J:202876).
molecularNote  A targeted mutation in exon 2 resulted in the amino acid substitution of glycine for alanine at position 56 (G56A). Cre-mediated recombination removed the floxed neomycin resistance cassette inserted downstream of exon 4.
  • mutations:
  • Nucleotide substitutions,
  • Insertion
  • synonyms:
  • SERT Ala56,
  • SERT Ala56,
  • Slc6a4 56Ala,
  • Slc6a4 56Ala
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

Trail: Allele

0 Driven By

13 Publication categories

Trail: Allele