| Primary Identifier | MGI:5518934 | Allele Type | Targeted |
| Attribute String | Humanized sequence | Gene | Trp53 |
| Transmission | Germline | Strain of Origin | (129X1/SvJ x 129S1/Sv)F1-Kitl<+> |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | Exon 5 was replaced with a modified one in which nucleotide substitutions (GA-to-AG) result in the amino acid substitution of glutamic acid with arginine at position 177 (p.E177R), mimicking a mutation found in some human tumors. Cre-mediated recombination removed the loxP site flanked puromycin resistance gene cassette inserted into intron 1. |
