| Primary Identifier | MGI:5523869 | Allele Type | Targeted |
| Attribute String | Null/knockout | Gene | Tet1 |
| Transmission | Germline | Strain of Origin | 129 |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | A loxP site was inserted upstream of exon 11. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 13. Cre-mediated recombination removed exons 11 and through 13 (encoding the critical catalytic domain in dioxygenases) and the neomycin resistance cassette. RT-PCR confirmed the absence of transcript expression in the cortex, hippocampus and cerebellum. |
