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Allele : Unc13a<tm4.1Bros> unc-13 homolog A; targeted mutation 4.1, Nils Brose
Primary Identifier  MGI:5523890 Allele Type  Targeted
Gene  Unc13a Transmission  Germline
Strain of Origin  Not Specified Is Recombinase  false
Is Wild Type  false
molecularNote  Exon 11 was replaced with one in which a point mutation (T to C) results in the amino acid substitution of arginine for tryptophan at position 464 (W464R). This mutation abolishes calcium-calmodulin binding. Cre-mediated recombination removed the floxed neomycin resistance cassette inserted downstream of the modified exon 11.
  • mutations:
  • Insertion,
  • Single point mutation
  • synonyms:
  • Munc13-1<W464R>,
  • Munc13-1<W464R>
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

6 Publication categories





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