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Allele : Apoe<tm1(APOE*)Ljohn> apolipoprotein E; targeted mutation 1, Lance Johnson
Primary Identifier  MGI:7562448 Allele Type  Targeted
Attribute String  Conditional ready, Humanized sequence Gene  Apoe
Transmission  Germline Strain of Origin  129S/SvEv
Is Recombinase  false Is Wild Type  false
molecularNote  Human APOE exons 2-4 were inserted into the mouse Apoe genomic sequence replacing mouse exons 2-4. In addition, human exon 4 and a stop codon are flanked by loxP sites followed by exon 4 from the APOE2 isoform, providing a conditional "switch".
  • mutations:
  • Insertion
  • synonyms:
  • APOE switch,
  • 4s2,
  • APOE switch,
  • 4s2
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1 Feature

Genome

1 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

0 Driven By

3 Publication categories





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