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Allele : Col1a1<tm1(tetO-EML4/ALK)Kkw> collagen, type I, alpha 1; targeted mutation 1, Kwok-Kin Wong

Primary Identifier	MGI:5527336	Allele Type	Targeted
Attribute String	Humanized sequence, Inducible, Inserted expressed sequence	Gene	Col1a1
Transmission	Germline	Strain of Origin	Not Specified
Induced With	doxycycline/tetracycline	Is Recombinase	false
Is Wild Type	false

molecularNote

The human EML4 and ALK variant 1 fusion under the control of the doxycycline inducible Tet-op promoter was knocked into the locus.

mutations:
Insertion

cellLines:
Not Specified

synonyms:
EML4-ALK,
EML4-ALK

earliestPublication:
Chen Z, et al. (2010) Inhibition of ALK, PI3K/MEK, and HSP90 in Murine Lung Adenocarcinoma Induced by EML4-ALK Fusion Oncogene. Cancer Res 70(23):9827-9836

1 Feature

Genome

2 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

0 Carried By

1 Driven By

7 Publication categories

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