| Primary Identifier | MGI:5524234 | Allele Type | Transgenic |
| Attribute String | Inserted expressed sequence | Gene | Tg(TG-BRAF*V600E)2Jaf |
| Strain of Origin | FVB/N | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | The human BRAF cDNA with a thymine-to-adenine transversion at position 1799A leading to a valine-to-glutamate substitution at residue 600 (V600E) and an NH2-terminal myc tag are under the control of the thyroid-specific bovine thyroglobulin promoter. Quantitative RT-PCR and Western blot analysis confirmed mRNA and protein expression in thyroid tissue. This line is the higher expressing line. Males show higher levels of expression than females. |
