| Primary Identifier | MGI:5527367 | Allele Type | Targeted |
| Gene | Bcl2l11 | Transmission | Germline |
| Strain of Origin | C57BL/6 | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | Nucleotide substitutions (TTCTCTTTT to GCTTCTGCT) within exon 3 result in the amino acid substitutions of alanine, serine and alanine for phenylalanine, serine and phenylalanine at positions 93, 94 and 95. These mutations in the Erk docking site (DEF2) abolishes Erk1/2 binding. This allele produces only an EL isoform lacking the phosphorylation sites associated with degradation of the protein. |
