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Allele : P3h1<tm1.1Brle> prolyl 3-hydroxylase 1; targeted mutation 1.1, Brendan Lee

Primary Identifier  MGI:5532323 Allele Type  Targeted
Attribute String  Hypomorph Gene  P3h1
Transmission  Germline Strain of Origin  129S7/SvEvBrd-Hprt1<b-m2>
Is Recombinase  false Is Wild Type  false
molecularNote  An H662A (histidine to alanine; CAT to GCT) mutation was introduced to a catalytic site encoded by exon 14 via a recombineering strategy. A loxP-flanked neomycin resistance selection cassette was placed upstream, in intron 13. Germ line, cre-mediated recombination removed the neomycin cassette. Please note that an error in the publication indicates that the mutation was introduced into exon 12, the correct exon is 14.
  • mutations:
  • Insertion,
  • Nucleotide substitutions
  • synonyms:
  • Lepre1<H622A>,
  • Lepre1<H622A>
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

0 Driven By

5 Publication categories