Primary Identifier | MGI:5544194 | Allele Type | Transgenic |
Attribute String | Humanized sequence, Inserted expressed sequence | Gene | Tg(Thy1-VAPB*P56S,-EGFP)D3Cai |
Strain of Origin | C57BL/6 | Is Recombinase | false |
Is Wild Type | false |
molecularNote | The human VAPB cDNA with a substitution of proline with serine at residue 56 (P56S) is under the control of a pan-neuronal promoter Thy1.2. Three lines were generated. qRT-PCR indicated more than 20-fold overexpression of mRNA. Protein expression was detected in the cerebral cortex, spinal cord, striatum, and hippocampus. |