Primary Identifier | MGI:5543909 | Allele Type | Transgenic |
Attribute String | Dominant negative, Inserted expressed sequence | Gene | Tg(Amh-SMAD2*)#Jebu |
Strain of Origin | FVB/N | Is Recombinase | false |
Is Wild Type | false |
molecularNote | This transgene consists of a mouse minimal Mullerian-inhibiting substance promoter (-180 bp), an epitope Flag tag, a C-terminal truncation of the human Smad2 gene resulting in a dominant negative effect, and a human GH polyadenylation sequence. The Amh promoter drives transgene expression in testicular Sertoli cells and ovarian granulosa cells. |