| Primary Identifier | MGI:5554188 | Allele Type | Transgenic |
| Attribute String | Inducible, Inserted expressed sequence | Gene | Tg(tetO-MAPT*K280*I277P*I308P,-luc)#Eman |
| Strain of Origin | Not Specified | Induced With | doxycycline/tetracycline |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | The tetracycline response element with a bidirectional CMV promoter drives inducible expression of the four-repeat domain on human MAPT (TauRD; 244-372 aa) carrying the frontotemporal dementia and parkinsonism linked to chromosome 17 Lys280 deletion (deltaK280) and two proline mutations in the hexapeptide motifs, I277P and I308P, and a luciferase gene. The Lys280 deletion accelerates aggregation while the proline mutations inhibit MAPT (Tau) aggregation. |
