| First Author | Renden RB | Year | 2024 |
| Journal | Commun Biol | Volume | 7 |
| Issue | 1 | Pages | 287 |
| PubMed ID | 38459113 | Mgi Jnum | J:348966 |
| Mgi Id | MGI:7612834 | Doi | 10.1038/s42003-024-05996-y |
| Citation | Renden RB, et al. (2024) Modulatory effects of noradrenergic and serotonergic signaling pathway on neurovascular coupling. Commun Biol 7(1):287 |
| abstractText | Dynamic changes in astrocyte Ca(2+) are recognized as contributors to functional hyperemia, a critical response to increased neuronal activity mediated by a process known as neurovascular coupling (NVC). Although the critical role of glutamatergic signaling in this process has been extensively investigated, the impact of behavioral state, and the release of behavior-associated neurotransmitters, such as norepinephrine and serotonin, on astrocyte Ca(2+) dynamics and functional hyperemia have received less attention. We used two-photon imaging of the barrel cortex in awake mice to examine the role of noradrenergic and serotonergic projections in NVC. We found that both neurotransmitters facilitated sensory stimulation-induced increases in astrocyte Ca(2+). Interestingly, while ablation of serotonergic neurons reduced sensory stimulation-induced functional hyperemia, ablation of noradrenergic neurons caused both attenuation and potentiation of functional hyperemia. Our study demonstrates that norepinephrine and serotonin are involved in modulating sensory stimulation-induced astrocyte Ca(2+) elevations and identifies their differential effects in regulating functional hyperemia. |
