| Primary Identifier | MGI:5559989 | Allele Type | Transgenic |
| Attribute String | Constitutively active, Inserted expressed sequence | Gene | Tg(Myh6-PRKCE*A159E)388Robo |
| Strain of Origin | FVB | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | Full-length rabbit PRKCE with the A to E substitution at amino acid 159 is under the control of the mouse alpha-myosin heavy chain promoter. This mutation prevents the pseudosubstrate domain from binding to the catalytic domain and renders it constitutively active. Northern blot analysis indicates 15-fold increase in PRKCE mRNA level and immunoblot analysis shows 9-fold increase in protein. |
