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Publication : In vivo detection of optically-evoked opioid peptide release.

First Author  Al-Hasani R Year  2018
Journal  Elife Volume  7
PubMed ID  30175957 Mgi Jnum  J:269817
Mgi Id  MGI:6269257 Doi  10.7554/eLife.36520
Citation  Al-Hasani R, et al. (2018) In vivo detection of optically-evoked opioid peptide release. Elife 7:e36520
abstractText  Though the last decade has seen accelerated advances in techniques and technologies to perturb neuronal circuitry in the brain, we are still poorly equipped to adequately dissect endogenous peptide release in vivo. To this end we developed a system that combines in vivo optogenetics with microdialysis and a highly sensitive mass spectrometry-based assay to measure opioid peptide release in freely moving rodents.
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