| First Author | Kitamura T | Year | 2014 |
| Journal | Science | Volume | 343 |
| Issue | 6173 | Pages | 896-901 |
| PubMed ID | 24457215 | Mgi Jnum | J:207487 |
| Mgi Id | MGI:5558983 | Doi | 10.1126/science.1244634 |
| Citation | Kitamura T, et al. (2014) Island cells control temporal association memory. Science 343(6173):896-901 |
| abstractText | Episodic memory requires associations of temporally discontiguous events. In the entorhinal-hippocampal network, temporal associations are driven by a direct pathway from layer III of the medial entorhinal cortex (MECIII) to the hippocampal CA1 region. However, the identification of neural circuits that regulate this association has remained unknown. In layer II of entorhinal cortex (ECII), we report clusters of excitatory neurons called island cells, which appear in a curvilinear matrix of bulblike structures, directly project to CA1, and activate interneurons that target the distal dendrites of CA1 pyramidal neurons. Island cells suppress the excitatory MECIII input through the feed-forward inhibition to control the strength and duration of temporal association in trace fear memory. Together, the two EC inputs compose a control circuit for temporal association memory. |
