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Allele : Flt3<tm1.1Dosm> FMS-like tyrosine kinase 3; targeted mutation 1.1, Donald Small
Primary Identifier  MGI:5565508 Allele Type  Targeted
Attribute String  Constitutively active Gene  Flt3
Transmission  Germline Strain of Origin  129
Is Recombinase  false Is Wild Type  false
molecularNote  Exon 14 was replaced with an exon 14 into which the internal tandem duplication (ITD) AGGACTGATTTCAGCGAA from a patient with acute myeloid leukemia was inserted. A floxed neo cassette was placed downstream of exon 15. Cre mediated recombination removed the neo cassette.
  • mutations:
  • Single point mutation,
  • Insertion
  • synonyms:
  • FLT3/ITD,
  • FLT3/ITD
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

0 Driven By

8 Publication categories





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