| Primary Identifier | MGI:5568245 | Allele Type | Transgenic |
| Attribute String | Inducible, Recombinase | Gene | Tg(Upk2-icre/ERT2)1Ccc |
| Strain of Origin | (C57BL/6 x CBA)F1 | Induced With | tamoxifen |
| Is Recombinase | true | Is Wild Type | false |
| molecularNote | The bMQ-343M5 mouse bacterial artificial chromosome (BAC) containing the entire Upk2 gene (and parts of the Foxr1 and Cxcr5 genes, and the Bcl9l gene) was modified by inserting the icre/ERT2 fusion protein-coding sequence followed by a polyA signal into the ATG initiation start site of the Upk2 gene. The transgenic construct was injected into fertilized C57BL/6 x CBA)F1 mouse eggs. Two founders were obtained (#1 having 2 copies of the transgene and #5 with 4 copies). Only #1 was able to produce offspring, and this line was used for further analyses. |
