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Allele : Deaf1<tm1.2Mico> DEAF1, transcription factor; targeted mutation 1.2, Michael Collard

Primary Identifier	MGI:5576139	Allele Type	Targeted
Attribute String	Null/knockout	Gene	Deaf1
Transmission	Germline	Strain of Origin	129
Is Recombinase	false	Is Wild Type	false

molecularNote

A loxP site was inserted in intron 1 and a floxed neo resistance cassette was inserted in intron 5. Cre excision of the resistance cassette left exons 2, 3, 4, and 5 flanked by loxP sites. Further cre expression in germline cells deleted the floxed exons.

mutations:
Insertion,
Intragenic deletion

cellLines:
Not Specified

earliestPublication:
Vulto-van Silfhout AT, et al. (2014) Mutations affecting the SAND domain of DEAF1 cause intellectual disability with severe speech impairment and behavioral problems. Am J Hum Genet 94(5):649-61

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

3 Carried By

0 Driven By

5 Publication categories

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