| First Author | Cyster JG | Year | 1994 |
| Journal | Nature | Volume | 371 |
| Issue | 6496 | Pages | 389-95 |
| PubMed ID | 7522305 | Mgi Jnum | J:211325 |
| Mgi Id | MGI:5574481 | Doi | 10.1038/371389a0 |
| Citation | Cyster JG, et al. (1994) Competition for follicular niches excludes self-reactive cells from the recirculating B-cell repertoire. Nature 371(6496):389-95 |
| abstractText | Two different approaches to follow clones of B lymphocytes in a diverse preimmune repertoire reveal a new process for eliminating self-reactive cells in the periphery which depends on competition between cells with different specificities. A key feature of this censoring mechanism is the selective exclusion of self-antigen-binding B cells from the normal migration route into lymphoid follicles, resulting in their premature death. This is a striking example of homeostasis by cellular competition for limiting niches and may explain the paradoxical association between immunodeficiency and autoimmunity. |
