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Allele : Asxl1<tm1.1Iaai> ASXL transcriptional regulator 1; targeted mutation 1.1, Iannis Aifantis

Primary Identifier	MGI:5575656	Allele Type	Targeted
Attribute String	Conditional ready, No functional change	Gene	Asxl1
Transmission	Germline	Strain of Origin	(C57BL/6 x 129S/SvEv)F1
Is Recombinase	false	Is Wild Type	false

molecularNote

Two loxP sites flanking exon 5-10 and an Frt-flanked neomycin selection cassette were inserted in the upstream intron. Flp-mediated recombination removed the neomycin cassette and left exons 5-10 floxed.

mutations:
Insertion

cellLines:
Not Specified

synonyms:
Asxl1<fl>,
Asxl1<fl>

earliestPublication:
Abdel-Wahab O, et al. (2013) Deletion of Asxl1 results in myelodysplasia and severe developmental defects in vivo. J Exp Med 210(12):2641-59

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

1 Carried By

0 Driven By

10 Publication categories

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