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Allele : Tg(DMD)72Thoen transgene insertion 72, Peter 't Hoen
Primary Identifier  MGI:5578554 Allele Type  Transgenic
Attribute String  Humanized sequence, Inserted expressed sequence Gene  Tg(DMD)72Thoen
Transmission  Germline Strain of Origin  (DBA/2 x 129P2/OlaHsd)F1
Is Recombinase  false Is Wild Type  false
molecularNote  The construct consists of a 2.7 Mbp yeast artificial chromosome (YAC) sequence containing the full-length 2.3 Mbp human dystrophin gene (DMD) and a hygromycin resistance cassette on one end and a neomycin resistance cassette on the other. Spheroplast fusion of YAC-containing yeast cells with murine (DBA2 x 129OLA)F1-derived embryonic stem (ES) cells resulted in ES cells with the integration of the transgene as a tail to tail duplication into mouse chromosome 5. Analysis by Western blot and human-specific antibody demonstrated the presence of full length protein at the sarcolemma.
  • mutations:
  • Insertion
  • synonyms:
  • hDMD,
  • hDMD
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1 Feature

Trail: Allele

Genome

1 Expresses

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0 Mutation Involves

Phenotype

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5 Carried By

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