| Primary Identifier | MGI:5581467 | Allele Type | Transgenic |
| Attribute String | Dominant negative, Inserted expressed sequence | Gene | Cables1 |
| Strain of Origin | (C57BL/6J x DBA/2J)F1 | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | RT-PCR analyses, long-range PCR and sequencing analyses showed that the genomic region from chr18:12,058,849 to 12,070,825 (build 38), including exon 4 of Cables1, was deleted at the transgene insertion site. A mutant small protein is able to be translated from the mutant allele in HEK293T cells when transfected with a Cables1-TAS expression vector. However, western blotting analysis with anti-Cables1 antibody (M-280) did not specifically detect wild-type or truncated Cables1 protein in brain lysate. |
