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Allele : Ryr2<tm4.1Amks> ryanodine receptor 2, cardiac; targeted mutation 4.1, Andrew R Marks

Primary Identifier  MGI:5582511 Allele Type  Targeted
Gene  Ryr2 Transmission  Germline
Strain of Origin  129 x C57BL/6 Is Recombinase  false
Is Wild Type  false
molecularNote  Exon 15 was replaced with a floxed neomycin resistance cassette and a modified exon 15 in which nucleotide substitution(s) result in the amino acid susbtitution of proline for leucine at position 433 (L433P). This mutation produces a leaky channel. Cre-mediated recombination removed the selection cassette.
  • mutations:
  • Insertion,
  • Nucleotide substitutions
  • synonyms:
  • RyR2-L433P,
  • RyR2-L433P
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

4 Publication categories