Primary Identifier | MGI:5582511 | Allele Type | Targeted |
Gene | Ryr2 | Transmission | Germline |
Strain of Origin | 129 x C57BL/6 | Is Recombinase | false |
Is Wild Type | false |
molecularNote | Exon 15 was replaced with a floxed neomycin resistance cassette and a modified exon 15 in which nucleotide substitution(s) result in the amino acid susbtitution of proline for leucine at position 433 (L433P). This mutation produces a leaky channel. Cre-mediated recombination removed the selection cassette. |