| First Author | Shi R | Year | 2018 |
| Journal | PLoS Pathog | Volume | 14 |
| Issue | 5 | Pages | e1007026 |
| PubMed ID | 29775486 | Mgi Jnum | J:269843 |
| Mgi Id | MGI:6275708 | Doi | 10.1371/journal.ppat.1007026 |
| Citation | Shi R, et al. (2018) Peroxidasin contributes to lung host defense by direct binding and killing of gram-negative bacteria. PLoS Pathog 14(5):e1007026 |
| abstractText | Innate immune recognition is classically mediated by the interaction of host pattern-recognition receptors and pathogen-associated molecular patterns; this triggers a series of downstream signaling events that facilitate killing and elimination of invading pathogens. In this report, we provide the first evidence that peroxidasin (PXDN; also known as vascular peroxidase-1) directly binds to gram-negative bacteria and mediates bactericidal activity, thus, contributing to lung host defense. PXDN contains five leucine-rich repeats and four immunoglobulin domains, which allows for its interaction with lipopolysaccharide, a membrane component of gram-negative bacteria. Bactericidal activity of PXDN is mediated via its capacity to generate hypohalous acids. Deficiency of PXDN results in a failure to eradicate Pseudomonas aeruginosa and increased mortality in a murine model of Pseudomonas lung infection. These observations indicate that PXDN mediates previously unrecognized host defense functions against gram-negative bacterial pathogens. |
