| Help | About | Contact Us

Allele : Tyr<em2Utr> tyrosinase; endonuclease-mediated mutation 2, University of Tsukuba Laboratory Animal Resource Center

Primary Identifier	MGI:5582798	Allele Type	Endonuclease-mediated
Attribute String	Not Specified	Gene	Tyr
Strain of Origin	C57BL/6J	Is Recombinase	false
Is Wild Type	false

molecularNote

Arginine codon 77 (CGT) in exon 1 was changed to leucine (CTT) (c.230G>T:p.R77L) using an sgRNA and an ssODN template with CRISPR/Cas9 technology. This allele was derived from mouse founder line #1 which also carries the 5-nucleotide-deletion allele Tyr^em1Utr in trans.

mutations:
Single point mutation

synonyms:
Tyr<G291T>,
Tyr<G291T>

earliestPublication:
Mizuno S, et al. (2014) Simple generation of albino C57BL/6J mice with G291T mutation in the tyrosinase gene by the CRISPR/Cas9 system. Mamm Genome 25(7-8):327-34

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

1 Carried By

0 Driven By

4 Publication categories

Questions? Comments? Click here!

MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Your name:
Your email address:
Subject:
Message:	---- Current page: ---- /mousemine/report.do?id=76516653

MouseMine