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Allele : Cd46<tm1Atk> CD46 antigen, complement regulatory protein; targeted mutation 1, John P Atkinson

Primary Identifier	MGI:5586970	Allele Type	Targeted
Attribute String	Null/knockout	Gene	Cd46
Transmission	Germline	Strain of Origin	129
Is Recombinase	false	Is Wild Type	false

molecularNote

The complement control protein repeat 1 (CCP 1) and almost all of the CCP 2a sequence of the Cd46 gene was replaced with a Neo cassette. Immunohistochemistry confirmed absence of protein in the epididymis. RT-PCR confirmed absence of mRNA in the eye and testis.

mutations:
Intragenic deletion,
Insertion

cellLines:
Not Specified

earliestPublication:
Lyzogubov V, et al. (2014) Complement regulatory protein CD46 protects against choroidal neovascularization in mice. Am J Pathol 184(9):2537-48

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

1 Carried By

0 Driven By

6 Publication categories

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