| Primary Identifier | MGI:5586989 | Allele Type | Targeted |
| Attribute String | Humanized sequence, Inserted expressed sequence | Gene | Gt(ROSA)26Sor |
| Transmission | Germline | Strain of Origin | Not Specified |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | The targeting construct inserted into the locus a wild-type human cDNA preceded by the cytomegalovirus early enhancer/chicken beta-actin promoter (CAG) element and a neomycin resistance cassette with a triple polyadenylation site flanked by loxP sites. Cre-mediated recombination removed the neomycin resistance cassette and allowed for expression of the human cDNA. Western blotting and ELISA indicate a fourfold elevation in SORL1 in the cortex and hippocampus of adult heterozygotes. |
