| Primary Identifier | MGI:5604241 | Allele Type | Transgenic |
| Attribute String | Constitutively active, Inserted expressed sequence | Gene | Tg(tetO-Fgfr3*R248C/Fgfr1)#Dor |
| Strain of Origin | FVB | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | This transgene consists of the tetracycline response element, a chimeric receptor consisting of the Fgfr3 extracellular and transmembrane domains with the R248C mutation fused to the Fgfr1 tyrosine kinase domain and a c-myc tag. The R248C mutation in Fgfr3 confers ligand-independent constitutive activity. By fusing this mutant Fgfr3 receptor to the Fgfr1 tyrosine kinase domain, a receptor that constitutively activates Fgfr1 signaling in the absence of ligand is produced. Four lines were produced however the pound symbol (#) is used because the line is not specified. |
