Primary Identifier | MGI:5609985 | Allele Type | Targeted |
Attribute String | Humanized sequence, Inserted expressed sequence, Null/knockout | Gene | Igh |
Transmission | Germline | Strain of Origin | (129S6/SvEvTac x C57BL/6NTac)F1 |
Is Recombinase | false | Is Wild Type | false |
molecularNote | Using BAC recombineering roughly 3 Mbp of the mouse locus including all of the Vh Dh and Jh gene segments was replaced with 340 kb of contiguous human sequence containing the equivalent human gene segments. The proximal junction of the replacement was placed about 200 bp downstream from the last J segment and the distal junction was placed about 9 kbp downstream from J558.55. |