Primary Identifier | MGI:5613978 | Allele Type | Transgenic |
Attribute String | Conditional ready, Inserted expressed sequence, No functional change | Gene | Tg(CMV-Plaur*)19Lbh |
Strain of Origin | FVB/N | Is Recombinase | false |
Is Wild Type | false |
molecularNote | The construct is designed with the CMV-IE enhancer/chicken beta-actin hybrid promoter (CAG; from the pCAGGS vector), a loxP-flanked transcriptional STOP cassette (containing beta galactosidase and a polyadenylation signal), and the soluble form of the murine urokinase-type plasminogen activator receptor (Plaur) gene. The soluble form of Plaur (suPAR) encodes a 60 kDa truncated protein, lacking the glycophosphatidylinositol (GPI) anchored three domain (commonly referred to as D1, D2, D3) protein. |