| Primary Identifier | MGI:5614071 | Allele Type | Targeted |
| Attribute String | Hypomorph | Gene | Rad50 |
| Inheritance Mode | Dominant | Transmission | Germline |
| Strain of Origin | 129/Sv | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | Nucleotide substitutions were introduced in exon 13, resulting in an amino acid substitution (p.V683R) in the Hook domain of the encoded peptide. A loxP site flanked neomycin resistance gene cassette was inserted into intron 13. The amino acid substitution introduces a charged residue in the vicinity of the cysteines that coordinate zinc and resulted in a hypomorphic allele. |
