| First Author | Griffiths EK | Year | 2001 |
| Journal | Science | Volume | 293 |
| Issue | 5538 | Pages | 2260-3 |
| PubMed ID | 11567140 | Mgi Jnum | J:146727 |
| Mgi Id | MGI:3838293 | Doi | 10.1126/science.1063397 |
| Citation | Griffiths EK, et al. (2001) Positive regulation of T cell activation and integrin adhesion by the adapter Fyb/Slap. Science 293(5538):2260-3 |
| abstractText | The molecular adapter Fyb/Slap regulates signaling downstream of the T cell receptor (TCR), but whether it plays a positive or negative role is controversial. We demonstrate that Fyb/Slap-deficient T cells exhibit defective proliferation and cytokine production in response to TCR stimulation. Fyb/Slap is also required in vivo for T cell-dependent immune responses. Functionally, Fyb/Slap has no apparent role in the activation of known TCR signaling pathways, F-actin polymerization, or TCR clustering. Rather, Fyb/Slap regulates TCR-induced integrin clustering and adhesion. Thus, Fyb/Slap is the first molecular adapter to be identified that couples TCR stimulation to the avidity modulation of integrins governing T cell adhesion. |
