| Primary Identifier | MGI:5618265 | Allele Type | Targeted |
| Attribute String | Conditional ready, Hypomorph | Gene | Clcn2 |
| Transmission | Germline | Strain of Origin | (129X1/SvJ x 129S1/Sv)F1-Kitl<+> |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | A floxed neo cassette was inserted into intron 1 and a loxP site was inserted into intron 3 via homologous recombination. Cre mediated recombination removed the neo cassette leaving exons 2 and 3 floxed and creating a mis-spliced intronic region. The splicing error leads to a frameshift at amino acid 7 and a premature stop codon. |
