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Allele : Gnao1<tm2.1Rneu> guanine nucleotide binding protein, alpha O; targeted mutation 2.1, Richard R Neubig

Primary Identifier  MGI:5620501 Allele Type  Targeted
Gene  Gnao1 Transmission  Germline
Strain of Origin  129S1/Sv-Oca2<+> Tyr<+> Kitl<+> Is Recombinase  false
Is Wild Type  false
molecularNote  Exon 5 was replaced with a modified exon 5 that contains nculeotide substitutions (GGC to AGT) that results in the amino acid substitution of serine for glycine at position 184 (G184S). This mutation blocks RGS binding. The floxed neo cassette inserted between the modified exon 5 and exon 6 was removed.
  • mutations:
  • Nucleotide substitutions,
  • Insertion
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

2 Carried By

0 Driven By

4 Publication categories