Primary Identifier | MGI:5620501 | Allele Type | Targeted |
Gene | Gnao1 | Transmission | Germline |
Strain of Origin | 129S1/Sv-Oca2<+> Tyr<+> Kitl<+> | Is Recombinase | false |
Is Wild Type | false |
molecularNote | Exon 5 was replaced with a modified exon 5 that contains nculeotide substitutions (GGC to AGT) that results in the amino acid substitution of serine for glycine at position 184 (G184S). This mutation blocks RGS binding. The floxed neo cassette inserted between the modified exon 5 and exon 6 was removed. |