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Allele : Dll1<tm3.1Gos> delta like canonical Notch ligand 1; targeted mutation 3.1, Achim Gossler

Primary Identifier  MGI:5620942 Allele Type  Targeted
Attribute String  Hypomorph, Inserted expressed sequence Gene  Dll1
Transmission  Germline Strain of Origin  Not Specified
Is Recombinase  false Is Wild Type  false
molecularNote  A Dll1 minigene (exons 1 to 9 as cDNA followed by the remainder of the Delta1 gene intron 9, exon 10, intron 10, and exon 11) with nucleotide substitutions that result in the amino acid substitutions of valine for threonine at postition 638 (T638V) and alanine for serine at positions 693 (S693A) and and 696 (S696A) and a floxed neomycin resistance cassette were inserted downstream of exon 1. Cre-mediated recombination removed the selection cassette.
  • mutations:
  • Insertion,
  • Intragenic deletion
  • synonyms:
  • Dll1<Dll1T638V,S693A,S696A>,
  • Dll1<Dll1T638V,S693A,S696A>
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

4 Publication categories