| First Author | Glyvuk N | Year | 2010 |
| Journal | EMBO J | Volume | 29 |
| Issue | 8 | Pages | 1318-30 |
| PubMed ID | 20203623 | Mgi Jnum | J:218588 |
| Mgi Id | MGI:5617942 | Doi | 10.1038/emboj.2010.15 |
| Citation | Glyvuk N, et al. (2010) AP-1/sigma1B-adaptin mediates endosomal synaptic vesicle recycling, learning and memory. EMBO J 29(8):1318-30 |
| abstractText | Synaptic vesicle recycling involves AP-2/clathrin-mediated endocytosis, but it is not known whether the endosomal pathway is also required. Mice deficient in the tissue-specific AP-1-sigma1B complex have impaired synaptic vesicle recycling in hippocampal synapses. The ubiquitously expressed AP-1-sigma1A complex mediates protein sorting between the trans-Golgi network and early endosomes. Vertebrates express three sigma1 subunit isoforms: A, B and C. The expressions of sigma1A and sigma1B are highest in the brain. Synaptic vesicle reformation in cultured neurons from sigma1B-deficient mice is reduced upon stimulation, and large endosomal intermediates accumulate. The sigma1B-deficient mice have reduced motor coordination and severely impaired long-term spatial memory. These data reveal a molecular mechanism for a severe human X-chromosome-linked mental retardation. |
