| Primary Identifier | MGI:5635256 | Allele Type | Targeted |
| Attribute String | Null/knockout | Gene | Tnnt1 |
| Transmission | Germline | Strain of Origin | 129P2/OlaHsd-Hprt1<b-m3> |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | LoxP sites were inserted into intron 10 and intron 13. Cre-mediated recombination removed exons 11 through 13. The predicted truncated product mimicks the protein involved in Amish nemaline myopathy. A FRT-flanked neomycin resistance cassette was inserted into intron 10. Western blot analysis confirmed the absence of protein expression in the soleus muscle. |
