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Allele : Shox2<tm1.1(Shox2*)Jfm> SHOX homeobox 2; targeted mutation 1.1, James F Martin
Primary Identifier  MGI:5636788 Allele Type  Targeted
Attribute String  Inserted expressed sequence Gene  Shox2
Transmission  Germline Strain of Origin  (129S6/SvEvTac x C57BL/6NCrl)F1
Is Recombinase  false Is Wild Type  false
molecularNote  A Flag-HA-Shox2a-DsRed-polyA cassette and an FRT flanked neo cassette were inserted at the start site in exon 1 via homologous recombination. Flp mediated recombination removed the neo cassette. The Shox2a cDNA encodes an N-terminal FLAG-HA- tagged full length Shox2 gene. The Shox2a cDNA has a heterologous 3'UTR releasing the gene from endogenous miRNA control. Immunofluorescence analysis indicates aberrant elevated expression of the mutant protein at E16.5 in the atrial septum.
  • mutations:
  • Insertion
  • synonyms:
  • Shox2<HA>,
  • Shox2<HA>
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1 Feature

Trail: Allele

Genome

1 Expresses

Trail: Allele

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

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9 Publication categories

Trail: Allele




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