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Allele : Sting1<tm1.2Camb> stimulator of interferon response cGAMP interactor 1; targeted mutation 1.2, John C Cambier

Primary Identifier	MGI:5639232	Allele Type	Targeted
Attribute String	Null/knockout	Gene	Sting1
Transmission	Germline	Strain of Origin	C57BL/6N-A<tm1Brd>
Is Recombinase	false	Is Wild Type	false

molecularNote

An FRT-flanked neo cassette followed by a loxP site was inserted intron 5. A second loxP site was inserted in intron 2. Flp-mediated recombination removed the FRT-flanked neo cassette leaving exons 3 through 5 floxed. Cre-mediated recombination removed exons 3 through 5.

mutations:
Intragenic deletion,
Insertion

cellLines:
Not Specified

earliestPublication:
Jin L, et al. (2011) MPYS is required for IFN response factor 3 activation and type I IFN production in the response of cultured phagocytes to bacterial second messengers cyclic-di-AMP and cyclic-di-GMP. J Immunol 187(5):2595-601

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

2 Carried By

0 Driven By

67 Publication categories

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