| First Author | Natsubori A | Year | 2023 |
| Journal | Neurosci Res | Volume | 191 |
| Pages | 48-56 | PubMed ID | 36549387 |
| Mgi Jnum | J:341649 | Mgi Id | MGI:7413767 |
| Doi | 10.1016/j.neures.2022.12.008 | Citation | Natsubori A, et al. (2022) Region-specific involvement of ventral striatal dopamine D2 receptor-expressing medium spiny neurons in nociception. Neurosci Res |
| abstractText | The ventrolateral striatum (VLS), a subregion of the ventral striatum (VS), possesses distinct neuronal Ca(2+) activities and functions in reward-oriented behavior, compared with the ventromedial striatum (VMS) based on the anatomical feature. We hypothesized that the VLS exhibits unique neuronal activity and function in nociceptive processing, a part of aversive processing. Using fiber photometry to monitor the neuronal Ca(2+) activities, we demonstrated that acute noxious mechanical stimuli like tail-pinch increased the Ca(2+) activity of dopamine D2 receptor-expressing medium spiny neurons (D2-MSNs) in the VLS in correlation with the stimulus intensities in mice, whereas mechanical stimuli increased the VMS D2-MSN activity independent of the stimulus intensities. Likewise, thermal stimuli decreased the VLS and VMS D2-MSN Ca(2+) activities during nociceptive behaviors in the hot plate test. Furthermore, the VLS D2-MSNs increased their Ca(2+) activity accompanied by formalin-induced nociceptive behaviors in mice, whereas the VMS D2-MSNs decreased it. The optogenetic inhibition of VLS D2-MSN activity increased the formalin-induced pain-related behavior in mice, thus suggesting the inhibitory effect of VLS D2-MSN activity on chemical nociceptive behavior, in contrast to previous reports that the VMS D2-MSNs could not involve the behavior. Therefore, the VLS D2-MSNs exhibited region-specific roles in nociception. |
